Recently, mutations in the FLG2 gene, in particular a nonsense mutation, were shown to be associated with persistent AD in a cohort of 60 US patients of African ancestry.18FLG2 encodes filaggrin-2, another S100 fused-type protein.19 Filaggrin-2 is very similar to filaggrin in terms of protein structure, amino-acid composition, pattern of expression and of biochemical properties. Here, FLG2 is linked to Alzheimer disease.