ANXA1 and breast cancer: de Graauw et al.43 validated the mRNA levels of ANXA1 in both luminal- and basal-like breast cancer cells, and the results showed upregulated mRNA levels of ANXA1 in basal-like breast cancer cells whereas luminal-like breast cancer cells showed reduced mRNA levels of ANXA1.43 These different expression patterns of ANXA1 highlight that ANXA1 may be regulated by different mechanisms.