ANXA1 and familial pancreatic carcinoma: For example, downregulated expression of ANXA1 is shown in thyroid cancer, prostate cancer, head and neck cancer, esophageal cancer, hairy cell leukemia (HCL), and B-cell non-Hodgkin's lymphomas.35, 36, 37, 38, 39, 40 However, it is also reported that ANXA1 is overexpressed in hepatocarcinoma and pancreatic cancer.41, 42 Moreover, in breast cancer, the expression of ANXA1 may be dependent on specific subtypes.