For example, downregulated expression of ANXA1 is shown in thyroid cancer, prostate cancer, head and neck cancer, esophageal cancer, hairy cell leukemia (HCL), and B-cell non-Hodgkin's lymphomas.35, 36, 37, 38, 39, 40 However, it is also reported that ANXA1 is overexpressed in hepatocarcinoma and pancreatic cancer.41, 42 Moreover, in breast cancer, the expression of ANXA1 may be dependent on specific subtypes. This evidence concerns the gene ANXA1 and Familial prostate cancer.