Such altered affinity of HAUSP to p53 leads to DNA repair and tumor-suppressive functions of p53.8, 9, 10 In addition to Mdm2 and p53, further studies have revealed that HAUSP can regulate various substrates, including ataxin-1, Chfr, claspin, Daxx, FOXO4, histone H2B, PTEN, NF-κB, Tip60, UbE2E1, and UVSSA.2 These findings suggest that HAUSP has diverse roles in the cell through the regulation of different substrates and other additional proteins. This evidence concerns the gene TP53 and neoplasm.