This unexpected result may be derived from multiple functions of ANXA1, which can be the main causes of different expression levels and roles of ANXA1 in different types of cancers.30, 31, 32, 33 Thus, we concluded that the failure of deubiquitination of ANXA1 by the depletion of HAUSP leads to reduced stability and cleavage of ANXA1 in the case of Jurkat cells, indicating that HAUSP is a positive regulator for ANXA1 in Jurkat cells. The gene discussed is ANXA1; the disease is cancer.