Such altered affinity of HAUSP to p53 leads to DNA repair and tumor-suppressive functions of p53.8, 9, 10 In addition to Mdm2 and p53, further studies have revealed that HAUSP can regulate various substrates, including ataxin-1, Chfr, claspin, Daxx, FOXO4, histone H2B, PTEN, NF-κB, Tip60, UbE2E1, and UVSSA.2 These findings suggest that HAUSP has diverse roles in the cell through the regulation of different substrates and other additional proteins. Here, USP7 is linked to neoplasm.