de Graauw et al.43 validated the mRNA levels of ANXA1 in both luminal- and basal-like breast cancer cells, and the results showed upregulated mRNA levels of ANXA1 in basal-like breast cancer cells whereas luminal-like breast cancer cells showed reduced mRNA levels of ANXA1.43 These different expression patterns of ANXA1 highlight that ANXA1 may be regulated by different mechanisms. This evidence concerns the gene ANXA1 and breast carcinoma.