Previous studies have indicated that Ets-1 is transcriptionally upregulated and promotes the expression of downstream hypoxia-inducible genes, in both HIF dependent and independent ways.16, 17 These Ets-1 target genes participate in a wide range of hypoxic responses, including angiogenesis,18, 19 energy metabolism remodeling 20 and tumor invasion.21, 22. Here, ETS1 is linked to neoplasm.