dJNK signaling is essential for morphogenetic processes, wound healing, response to pathogens, tumor development, compensatory cell proliferation and apoptosis.18 In mammals, jnk1/jnk2-double knockout mice exhibit abnormal development of the embryonic brain, likely through inhibition of apoptosis,19 but there is little data about the role of the JNK pathway during Drosophila CNS development.20 Here, MAPK8 is linked to neoplasm.