ORAI1 and breast cancer: SOC-mediated sustained increase in the cytosolic Ca2+ has shown to trigger apoptosis in tumor cells.109 STIM1-ORAI1 driven store-operated calcium entry seems to be indispensable for migration and metastasis of breast cancer, cervical cancer and hepatocarcinoma, which was potently blocked by the store-operated calcium entry inhibitor.110, 111, 112, 113 Moreover, CRAC channels are implicated in VEGF-activated Ca2+ influx promoting angiogenesis, which might be crucial for cancer progression.111