As an example, overexpression of Kv1.1 and Kv1.3 are found in glioma, lymphoma, breast, lung, pancreas and prostate cancer.49, 63 Furthermore, Kv1.3 channel overexpression is also linked with resistance to apoptosis as shown by the upregulation of Kv1.3 expression in diffuse large B-cell lymphoma and glioma.64 This evidence concerns the gene KCNA1 and central nervous system cancer.