ORAI1 and cancer: Thus, ion channels are involved in migration, which plays a major role in the initiation of metastasis process.75 As an example, BKCa and SKCa channels are implicated in metastasis as they have been shown to promote breast cancer cell migration.76 Furthermore, SKCa channels form a complex with the ORAI1 channel for localized calcium entry within lipid rafts in order to enhance cancer cell migration and metastasis.77 In general, overexpression of Kca1.1 and Kca3.1 has been shown in bone, brain, breast, ovary, pancreas cancers and brain, gastrointestinal tract, melanoma and prostate cancers.