DSP and Genetic epidermal disorder: Desmoplakin is an abundant desmosomal protein and epidermal genetic disorders are associated with mutation of the desmoplakin gene.27 Desmoplakin haploinsufficiency is associated with striate palmoplantar keratoderma27, 28 and a desmoplakin mutant causes autosomal recessive cardiomyopathy-associated PPK.28 Plakoglobin mutations are associated with autosomal recessive Naxos Syndrome29 and plakoglobin null mice display a severe skin phenotype.30 DSCs and DSGs are core components to the desmosome that are expressed in epidermis.