To further assess the impact of MIC-1/GDF15 on prostate cancer growth, at 4–6 weeks of age, we pre-assigned another cohort of 88 TRAMPMIC+/+ and 88 TRAMPMIC-/- mice to be culled progressively at four predefined time point up to 33 weeks of age. The gene discussed is GDF15; the disease is Familial prostate cancer.