For others, conversely, the network suggests risk loci to participate in far-cis- and trans-regulation of genes implicated in cancer, including TRPS1 (8q23)29, TPO (10p14)30, VEZT (12q13)31 and RAN (12q13)32, all recurrently mutated in CRC33, 34 (Supplementary Figs 5–22). This evidence concerns the gene VEZT and cancer.