TPO and cancer: For others, conversely, the network suggests risk loci to participate in far-cis- and trans-regulation of genes implicated in cancer, including TRPS1 (8q23)29, TPO (10p14)30, VEZT (12q13)31 and RAN (12q13)32, all recurrently mutated in CRC33, 34 (Supplementary Figs 5–22).