PTAFR and melanoma: The IC50 of BITC in PAF-R deficient murine B16-MSCV cells was ~11 mM and in the human SK5MEL cells was >50 μM. These findings indicated that PAF-R signaling augments the decreased survival of the melanoma cells, which is elicited by BITC, at a lower concentration than is required for the PAF-R-deficient cells.