Further experiments [6–8] revealed that when a small amount of tumour cells was implanted into healthy tissue, they managed to coopt and migrate along host vessels, as well as producing many chemical substances, such as VEGF, Ang-1, and Ang-2, to change the microenvironment around the host vessels, which can induce immature changes in the host tissue vasculature, including vessel dilation, increased capillary permeability, and tortuosity [9]. Here, VEGFA is linked to neoplasm.