HMGB1 and acute pancreatitis: Meanwhile, Wang et al. have observed that the serum level of HMGB1 was significantly increased in the second day of hospitalization when compared with that in the first day of hospitalization, and the elevated serum level of HMGB1 in the patients with acute pancreatitis maintained a high level along with the length of stay, indicating that the upregulated HMGB1 level may be connected with the development of pancreatitis [32].