On the other hand a recent three-center study of a series of 65 cases of vulvar and vaginal melanomas, detected no mutations of BRAF, a 12% mutation frequency of NRAS, and c-KIT amplification at the same frequency, while c-KIT mutations appeared to be specific for vulvar melanomas (18%), since they were undetected in vaginal melanomas [39], confirming the findings of a previous study [24]. This evidence concerns the gene KIT and vulvar melanoma.