In contrast to the numerous mutational data in cutaneous melanomas, very limited data are available [23–28], concerning either the full spectrum of mutational events affecting the MAPK/ERK, PI3K/AKT, and GNAQ/11 pathways in female genital tract melanomas or the DNA mismatch repair (MMR) status [29] in the same type of malignancy. The gene discussed is GNAQ; the disease is cutaneous melanoma.