In Leigh syndrome MT-ATP6, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND5, MT-ND6, MT-TK, MT-TV, and MT-TW are listed, in which 8 genes are under regulation of miRNA but genes MT-TK and MT-TV do not have any miRNA targets. The gene discussed is MT-ND5; the disease is Leigh syndrome.