CALCA and neoplasm: Among these peptides, calcitonin, CGRP, and amylin have been implicated as mediators of several pathologies such as cardiovascular and renal disorders, sepsis, inflammation, and diabetes [11]; adrenomedullin is expressed in a variety of tumors where it aggravates several of the molecular and physiological features of malignant cells and has been shown to be a mitogenic factor stimulating growth in several cancer types and to encourage a more aggressive tumor phenotype [12–15].