It was noticed that a rare subset of individuals with germline SDHB or SDHD mutations in the European–American pheochromocytoma registry had renal cancers and papillary thyroid cancer (PTC) (Neumann et al. 2004, Vanharanta et al. 2004). The gene discussed is SDHB; the disease is hereditary pheochromocytoma-paraganglioma.