When our pilot of 48 apparently sporadic DTC samples revealed germline variation in SDHB and SDHD, we expanded our series to a total of 241 unrelated PTEN mutation negative research participants with differentiated thyroid carcinoma (Nagy et al. 2011) from The Ohio State University's (OSU) Thyroid Center. The gene discussed is PTEN; the disease is differentiated thyroid carcinoma.