SDHD and thyroid cancer: A recent in vitro study specifically in thyroid cancer cell lines also showed that SDHD G12S and SDHD H50R variants lead to impaired PTEN function through alteration of its subcellular localization accompanied by resistance to apoptosis and induction of migration, mediated by Rous sarcoma protooncogene (SRC) (Yu et al. 2014).