FMR1 and fragile X syndrome: We selected 16 individuals from our in-house cohort of male patients with intellectual disability, for sequencing analysis of the FMR1. The selection was based on the presence of typical neurodevelopmental features of fragile X syndrome including moderate intellectual disability (IQ < 60), autistic and/or stereotypic behavior, and impaired social interaction, associated with at least one of the following physical features: elongated face, macroorchidism, and/or large ears.