Our data show that antipsychotics clinically effective in positive symptoms of schizophrenia, haloperidol, aripiprazole, and olanzapine have homologous temporal and spatial TFPs showing a transcriptional induction of c-fos, Arc, and Egr2, particularly in nucleus accumbens and striatum (Figs. 1 and 2). The gene discussed is EGR2; the disease is schizophrenia.