Second, agenesis/absence of the right kidney was noted in 2 of 12 cases of congenital abnormalities observed in offspring of women who were treated for chronic myelogenous leukemia during pregnancy with imatinib, a small molecule inhibitor of Kit and select other tyrosine kinases, including Pdgfra and Ret, which also play roles in renal development [60]. Here, PDGFRA is linked to chronic myelogenous leukemia, BCR-ABL1 positive.