Auto-inflammatory syndromes, such as neonatal onset multi-organ inflammatory disease that features arthropathy have been linked with mutations in the NACHT domain of NLRP3, while inflammatory arthropathies, such as rheumatoid arthritis and ankylosing spondylitis, have been associated with mutations in the TNF superfamily24, 59, 60. Here, TNF is linked to rheumatoid arthritis.