In the present meta-analysis, we find that the mean DOR values for CEA, Cyfra21–1, p53 antibody, SCC-Ag and VEGF-C were 16.67, 34.56, 22.88, 24.99 and 7.97, respectively, indicating that, although not as good as expected, measurement of these four tumor markers could be helpful in the diagnosis of EC. Here, TP53 is linked to neoplasm.