Though this seems compelling for the development of positive modulators for Kv7.1 channels for the treatment of urinary incontinence, it must be stated that Kv7.1 channels are important in heart tissue [50,51] and therefore the risk of side effects renders Kv7.1 channels as an improper target in the bladder. This evidence concerns the gene KCNQ1 and Urinary incontinence.