ABCA3 and Interstitial pneumonitis: Conversely, a subject (507) with the histological diagnosis of NSIP (non-specific interstitial pneumonitis) and in the absence of TTF1, SP-C or ABCA3 mutations had considerably reduced level of phosphatidylcholine and such changes of their lipid species profile suggesting the presence of as yet undetermined defects of the pulmonary surfactant system.