CLU and Axenfeld-Rieger syndrome: Several identified genes have human homologues, which are directly or indirectly involved in corneal dystrophies such as coch (coagulation factor C homolog, cochlin [37], dcn (decorin) [38], cx43. 4 [39], clu (clusterin) [40], foxc1a (Axenfeld-Rieger syndrome type 3 (RIEG3 #602482) and Iridogoniodysgenesis type 1 (IRID1 #601631)), kera (keratocan; posterior amorphous dystrophy [41]) and tgfbi (transforming growth factor, beta-induced; lattice corneal dystrophy [42]).