PSEN1 and neuroblastoma: In order to verify this hypothesis, we analyzed two genes (myogenin and PSEN1), each one in two experimental models: CD1 mouse embryos and C2C12 myoblast cells for myogenin and human brains and neuroblastoma SK-N-BE cells for PSEN1. In each model, we compared conditions with differential methylation profiles, as ascertained in previous studies [5, 10].