Specifically in CRC, Pyke et al., found that uPAR was strongly expressed in tumour-infiltrating macrophages, neutrophils and eosinophils (using immunohistochemistry (IHC)) but only weakly to moderately expressed in neoplastic tumour cells (using monoclonal antibodies (MAbs) against human uPAR clones R2 and R4) [9]. The gene discussed is PLAUR; the disease is neoplasm.