Other studies have suggested that smaller myocardial infarctions in TLR4-deficient mice can be attributed to reduced neutrophil infiltration and NF-κB activation followed by decrease in the levels of the inflammatory cytokines IL-1β and IL-6 as well as of monocyte chemotactic factor-1 [14, 17]. This evidence concerns the gene TLR4 and myocardial infarction.