CALR and neoplasm: On the other hand, as shown in Figure 5, calreticulin does not share with Hsp70 the capacity for gene expression and production to be upregulated in PDT-treated cells and be mobilized systemically as acute phase reactant, as evidenced by the upregulation of Hsp70 gene in the liver and spleen of mice bearing PDT-treated or a PDT vaccine-treated tumor (20, 24).