TGFB1 and gingival disorder: This inflammation could lead to the upregulation of several cytokine factors such as fibroblast growth factor-2 (FGF-2), transforming growth factor-β1 (TGF-β1), interleukin-6 and interleukin-1β (IL-6, IL-1β), and platelet derived growth factor-β (PDGF-β) predisposing the tissue to a localized toxic effect and the development of fibrotic gingival hyperplasia [5].