Upon the exclusion of SmHSP20 this analysis established that antigen-specific IgE magnitude prior to treatment was significantly negatively correlated with transcription levels for each antigen in eggs (β = −0.550, r2 = 0.2739, p = 0.038) an association that strengthened post-treatment with PZQ (β = −0.716, r2 = 0.3666, p = 0.013) as shown in Figure 6A. None of the other confounding variables, including geometric mean (GM) age, GM infection intensity, or GM IgG4 levels were found to significantly correlate with IgE levels. This evidence concerns the gene IGHE and infection.