Indeed studies in schistosomiasis mansoni endemic areas on the SmTAL family of EF-hand parallergens have shown that for antigens expressed exclusively in the adult worm stage of the parasite, such as SmTAL1 and SmTAL3, IgE responses only develop naturally over time as adult worms die or during treatment with praziquantel (PZQ), which damages adult worms and reveals cryptic antigens (24). This evidence concerns the gene IGHE and Schistosomiasis mansoni.