The miRNA-146a gene for example may be up-regulated 10-fold or more within minutes of viral infection; importantly NF-κB activation is usually terminated via IκB protein re-synthesis and NF-kB-re-inhibition (Schmid and Birbach, 2008; Hill et al., 2009, 2014; Cui et al., 2010; Lukiw et al., 2010). This evidence concerns the gene NFKB1 and viral infectious disease.