It is our opinion: (i) that NF-kB inhibition may not be an effective therapeutic strategy for neurotrophic viral infections because NF-kB is a ubiquitous transcription factor with large potential for off-target effects; and (ii) that virally-induced miRNA-146a excess could be effectively neutralized using perfectly complementary locked nucleic acid-stabilized anti-miRNA-146a oligonucleotides, and thereby act as an anti-viral agent for a wide variety of DNA- and RNA-virus-induced disease (Lukiw, 2013; Maguire et al., 2014). Here, NFKB1 is linked to viral infectious disease.