Also in cancer cell lines, IL-6 is able to affect both the expression and nuclear translocation of DNA methyltransferase 1 (DNMT1), consequently changing its activity within the cell (Hodge et al., 2001, 2007; Foran et al., 2010), and potentially targeting methylation to specific gene promoter regions (Li et al., 2012). The gene discussed is DNMT1; the disease is cancer.