BCR and Burkitt lymphoma: Previous studies have demonstrated that the development of Burkitt lymphoma is closely associated with mutations across the Id3 HLH region, that forced expression of Id2 in a murine model of BCR–ABL interferes with the development of chronic myeloid leukemia, and that Id3-deficient mice develop γδ T-cell lymphomas (Ko et al. 2008; Li et al. 2010; Schmitz et al. 2012).