Furthermore, Kyoto Encyclopedia of Genes and Genomics (KEGG) pathway analysis revealed p53 and genes associated with the PI3K–AKT, MAPK, and Rap1 pathways as well as genes involved in the suppression of inflammatory bowel disease as being affected by depletion of Id2 and Id3 expression (Fig. 5B). This evidence concerns the gene ID3 and inflammatory bowel disease.