Silencing of genes with reported immune-regulatory function, namely PD-L1, CEACAM-6, and galectin-3 (GAL-3), strongly reduced luciferase activity only in the cytotoxicity setup, whereby PD-L1 showed a higher impact on tumor lysis (Blank et al, 2004; Peng et al, 2008; Witzens-Harig et al, 2013). The gene discussed is LGALS3; the disease is neoplasm.