To further demonstrate that up regulation of LMO2 and NANOG by MUC16-Cter is indeed dependent on JAK2, MUC16-Cter (F114HA) was expressed in mouse mammary cancer cells with (Jak2+/+) and without Jak2 (Jak2−/−) [41] (Figure 4C). The gene discussed is MUC16; the disease is breast cancer.