NECTIN1 and Bowen disease of the skin: However, Matsushima et al. [27] reported that the expression of nectin-1α, one of the splice variants of nectin-1, was decreased in well-differentiated squamous cell carcinoma and basal cell carcinoma of the skin compared with that in the normal epidermis and Bowen’s disease, in spite of the preserved E-cadherin expression.