Betanin decreased protein glycation indexed by the relative lower methylglyoxal/ N-carboxymethyl lysine (CML) level and RAGE expression, and reduced glycative products in BSA/fructose system. Betanin also antagonized oxidative stress and NF-κB activation, all of them may be involved in the antifibrotic mechanisms. Food pigments may neutralize adverse effects of carbohydrate, i.e., diabetes and related syndrome, and complementary therapy with betanin may prove useful in attenuating the development of cardiac fibrosis in diabetes. This evidence concerns the gene NFKB1 and diabetes mellitus.