A role for SP has been demonstrated in neuroimmune and systemic autoimmune/inflammatory conditions, including multiple sclerosis (MS), rheumatoid arthritis and inflammatory bowel disease (Goode et al. 2000; Kostyk et al. 1989; Lotz et al. 1987; O’Connor et al. 2004; Weinstock 2014), as well as in infections and cancer. This evidence concerns the gene TFF2 and multiple sclerosis.