The therapeutic benefits of carboplatin and gemcitabine in patients with triple negative breast cancer were significantly enhanced by BSI-201 [36]; as BSI-201 has now been conclusively demonstrated to not inhibit PARP [37], it is possible that its nicotinamide pharmacophore affords it vasoactivity-dependent chemopotentiation. The gene discussed is PARP1; the disease is triple-negative breast carcinoma.