As for Alzheimer’s disease, Yahata et al. generated iPSC-derived neuronal cells, which expressed the forebrain marker Foxg 1 and neocortical markers CUX1, SATB2, CTIP2, and TBR1 and also amyloid precursor protein, β-secretase and γ-secretase components. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.