In Chr 12q23, variations near or within STAB2 are associated with coronary restenosis (P = 1.0 × 10-7) [12], coronary disease (P = 1.0 × 10-5) and stroke (P = 5.4 × 10-4), and those near IGF1 are associated with insulin resistance (P = 2.0 × 10-9). This evidence concerns the gene IGF1 and stroke disorder.