IL21 and hepatocellular carcinoma: In the present study, we found that the IL-21 levels secreted by Tfh cells from HCC patients were significantly decreased compared with those from HBV-LC individuals (2.4% ± 0.9% vs 5.7% ± 1.4%, p ˂ 0.001) and healthy controls (2.4% ± 0.9% vs 3.4% ± 1.2%, p = 0.035) (Fig. 4).