To validate the importance of Tfh-cell-related major soluble factors, Gabriela Bindea [16] investigated the expression of CXCL13, CXCR5, IL-21, and B-cell-related markers (MS4A1 and CD19) in relation to DFS in colorectal cancer; high Tfh cell marker (CXCL13 and CXCR5) expression was correlated with a significantly prolonged DFS. This evidence concerns the gene IL21 and colorectal cancer.