As to the lesion total HLA-G expression (with mAb 4H84), which was observed with no difference between patient with adenocarcinoma and squamous cell carcinoma, indicating that total HLA-G expression did not vary dramatically in these two histological type NSCLC patients; however, lesion total HLA-G expression was found to be significantly associated with disease clinical TNM stage and significantly associated with the poor prognosis and shorter survival time 11,12. The gene discussed is HLA-G; the disease is squamous cell carcinoma.