The low expression of miR-146a and miR-155, both on the top of the list of differentially expressed miRNAs in our study, as a constant feature in ALK+ ALCL, is intriguing because evidence suggests that these two miRNAs may have crucial roles in regulating the innate immune response and that the putative targets of both miRNAs are components of the toll-like receptor (TLR) signaling machinery [20,25]. This evidence concerns the gene ALK and anaplastic large cell lymphoma.