IL36RN and hyperinsulinemic hypoglycemia, familial, 4: Recessively inherited null and missense mutations in the genes encoding IL‐1Ra (IL1RN) and IL‐36Ra (IL36RN) can cause the development of severe pustular dermatoses,3, 5, 6, 7 and are now recognized as discrete clinical diagnoses: deficiency of IL‐36Ra disorder (DITRA)3; and deficiency of IL‐1Ra disorder (DIRA).5