The EWS gene is target of tumor-specific chromosomal translocations in Ewing's sarcoma family of tumours, myxoid liposarcoma, malignant melanoma of soft parts, desmoplastic small round cell tumor, small round cell sarcoma, acute leukaemia, extraskeletal myxoid chondrosarcoma, and others (Table 1). The gene discussed is EWSR1; the disease is Ewing sarcoma.