In RGCs, a cell line of immortalized retinal ganglion cells that express NGF and its receptors, TrkA and p75NTR, diabetes-induced peroxynitrite formation has been shown to impair TrkA receptor phosphorylation and activate the p75NTR-dependent proapoptotic pathway, leading to neuronal cell death [50]. The gene discussed is NGFR; the disease is diabetes mellitus.