Promising proteins from this line of investigation include: PTPRZ1 (receptor-type tyrosine-protein phosphatase zeta; function unclear but implicated in directional outgrowth of glioma cells), SEC61G (Protein transport protein Sec61 subunit gamma; involved in protein translocation across the endoplasmic reticulum for degradation), TNC (tenascin C; an extracellular glycoprotein typically expressed in development/differentiation and following injury), and EGFR (51). The gene discussed is PTPRZ1; the disease is central nervous system cancer.