In the presence of amplified EGFR, it has been found that regulation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway through IκBαM gene transfer could play a role in glioma angiogenesis by regulating the expression of vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) (37). This evidence concerns the gene EGFR and glioma.