CD4 and Cirrhosis: Due to splenic sequestration, cirrhosis and CD4 count variability has been polemic; however, one study used Fib-4 index, a correlation between the level of fibrosis and the CD4 count: [age (years) × aspartate(AST; IU/liter)]/platelet count (109/liter) × ALT (IU/liter)1/2]13.