DDIT3 and left ventricular hypertrophy: As a dihydropyridine calcium channel blocker, LAC could decrease blood pressure of SHR and inhibit the expression of GRP78 and CHOP with optimal dose of 0.72 mg/kg, which demonstrated that LAC could not only lower blood pressure but also protect left ventricular hypertrophy caused by pressure overload, improve cardiac function, and exert an antiapoptotic effect.